Exploring the roles of cyclophilins as possible linkers of aging and late onset neurodegenerative disorders.Grant Type: Charles E. Smith in honor of Prof. Joel Elkes Fellowships, Second Year
Institute: Molecular Biology, Hadassah Medical Center, The Hebrew Univeristy of Jerusalem
Late onset neurodegenerative disorders, such as Alzheimer’s (AD) and prion diseases, share a common feature; stemming from aberrant protein aggregation. Although it is unknown why these disorders emerge late in life, recent studies indicate that aging actively suppresses mechanisms that protect the young, exposing the aged organism to disease. We propose to study whether the protective activity of chaperone proteins that ensure correct, nonaggregative folding of other proteins is down-regulated by aging, enabling the onset of neurodegenerative disorders. Studying the mechanisms linking aging and neurodegeneration will open new avenues for the development of novel therapies based on manipulation of aging.
Keywords: Alzheimer's disease,