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Sharon Anavi Goffer



Cannabinoid-induced ADHD: CB1 or CB2 receptor-mediated?

Grant Type: Charles E. Smith in honor of Prof. Joel Elkes Fellowships, Second Year
Institute: Biology, Ariel College

Therapeutic effects of cannabis in patients with either or both Tourette Syndrome (TS) and Attention-Deficit Hyperactivity Disorder (ADHD) suggest the core involvement of the endogenous cannabinoid system in this disorder. The goal of this proposal is to study the role of the cannabinoid receptors in these disorders. Our preliminary data show that postnatal treatment with CB1 receptor inhibitor or with CB2 receptor stimulator induces ADHD-like behavior that last into adulthood. In addition, CB2 receptor stimulator induces motor tics at late stage of life, reminding symptoms of TS. Imaging the brain structure and comparing between the two models for ADHD will contribute to our understanding of the origin the different phenotypes in humans, supporting individual therapy and the development of new classes of drugs to treat patients with TS and/or ADHD.

Keywords:  Behavioral disorders,