Immunologic biomarkers related to ASDs development during pregnancy in high risk populationGrant Type: Young Investigator Grant, First Year
Institute: Departments of Obsterics and Gynecology, Hadassah Hebrew University Medical Center
Autism spectrum disorders (ASD) are neurodevelopmental disorders, currently estimated to affect 1% of children. ASD is diagnosed mostly around the age of two to three years old. Despite the high prevalence of autism, there are limited clues for its pathogenesis, early detection or treatment. Previous studies have shown abnormal immunologic profile for ASD children. We wish to further examine this profile, using a prospective study during pregnancy in high risk population, in order to find biomarkers that correlate with the appearance of ASD. We will focus particulary in the activity, responsivness and functionality of mast cells, eosinophils and natural killers (NK) cells. Our findings are likely to promote the understanding of ASD and eventually help precede diagnosis.