Epigenetic analysis of the prefrontal cortex and anterior cingulate cortex in humans with Autism Spectrum DisordersGrant Type: Young Investigator Grant, First Year
Institute: Faculty of Medicine, Bar Ilan University
Current research suggests that the major factors leading to Autism Spectrum Disorders (ASD) include genetics and prenatal environmental factors. A specific chemical modification of our genome, known as DNA methylation, is known to be caused by environmental factors. Therefore, we hypothesize that faulty DNA methylation of the genome in the brain may be a major factor leading to the development of ASD. The proposed research will determine genomic regions with significant differences in DNA methylation in the human brain between normal and autistic individuals. Subsequent animal studies will determine the behavioral and clinical significance of the observed changes.